5ÔÂ5ÈÕ-7ÈÕ£¬±±¾©´óѧµÚÈýÒ½ÔºµÚ¶þ½ìÃÚÄòϵÖ×ÁöרÌâÑÐÌÖ»áÔÚ¾©ÕÙ¿ª¡£ÃÀ¹ú¶Å¿Ë´óѧǰÁÐÏÙÖÐÐÄÖ÷ÈÎ Judd W. Moul¡¢ÃÀ¹úÈý̩ҽѧÊý¾ÝÑо¿ËùÊ×ϯ¿ÆÑ§¼ÒËïÁ¢Ó¢½ÌÊÚ¡¢Ì¨Íą̊´óҽѧԺ¸½ÉèÒ½ÔºÖ÷ÈÎÆÑÓÀТ½ÌÊÚ¡¢Öйú¹¤³ÌԺԺʿ/ɽ¶«Ê¡Ö×ÁöÒ½ÔºÔº³¤ÓÚ½ðÃ÷½ÌÊÚ¡¢ÖлªÒ½Ñ§»áÃÚÄòÍâ¿ÆÑ§·Ö»áºòÈÎÖ÷ÈÎίԱ»Æ½¡½ÌÊÚ¡¢°²»ÕÒ½¿Æ´óѧµÚÒ»¸½ÊôÒ½ÔºÊé¼ÇÁº³¯³¯½ÌÊÚµÈÖî¶àº£ÄÚÍâ¶¥¼âר¼Ò³öϯ£¬È«¹úËİٶàÃûÃÚÄòÍâ¿ÆÒ½Ê¦²Î»á¡£±±¾©´óѧµÚÈýÒ½ÔºÃÚÄòÍâ¿ÆÖ÷ÈÎÂíºÁÖ½ÌÊÚΪ´ó»áÖ÷ϯ¡£

Judd W.MoulÖ¸³ö£ºÏÖ´úǰÁÐÏÙ°©¸ùÖÎÊõÐ뽫ÆäÄÉÈëµ½Ò»¸ö¶àѧ¿Æ¡¢¶àÄ£¿éµÄÕïÁƼƻ®µ±ÖС£ÔÚÄÚ·ÖÃÚÖÎÁƺÍRPÓÐЧÐÔÖÐÌá³öÁËÁ½Ïî×î¼ÑµÄÖ§³ÖÊý¾Ý£ºECOG¡ª3886 ÊÔÑé¡¢±È¿¨Â³°·£¨150mg£©EPCÊÔÑé¡£¶øÐÂÓ¢¸ñÀ¼ÔÓÖ¾2017Äê2Ô¹«²¼µÄ·ÅÁÆÁªºÏ±È¿¨Â³°·150mg Qd µÄÑÖ¤Ñо¿½á¹û±íÃ÷150mg Qd¿ÉÒÔ¸ø»¼Õß´øÀ´¸ü¶àµÄÑ¡Ôñ¡£Óë»áÕß·×·×ÔĶÁ¸ÃÎÄÕ³éÓ¡°æ¡£
ǰÃÀ¹úʳƷҩƷ¹ÜÀí¾Ö£¨FDA£©ÆÀÉó×鳤/ÃÀ¹ú¶Å¿Ë´óѧǰÁÐÏÙÖÐÐÄÊý¾Ý¿âºÍ×éÖ¯¿âÖ÷ÈÎËïÁ¢Ó¢½ÌÊÚ×÷¡°±±ÃÀ°©Ö¢´óÊý¾ÝºÍÓ¦ÓöÔÖйúµÄÆôʾ¡±Ö÷Ìⱨ¸æ¡£
ÌÀƽ¡¢¸µÇ¿µÈ¶Å¿Ë´óѧÍŶÓר¼ÒÕ¹¿ªÁËÈÈÁÒÌÖÂÛ£¬¶ÔÊÀ½ç×îнøÕ¹£¬ÃÀ¹úǰÁÐÏÙ°©´óÊý¾Ý¶ÔÖйúµÄÆôʾ¡¢T1HGºÍT1G3Ö×ÁöµÄ²¡ÀíÑ§ÌØÕ÷×÷Á˾«²Ê»¥¶¯¡£Öйúҽʦ±¨¶ÔÒÔJudd W.MoulΪÊ׵ĶſËÍŶӽøÐÐÁ˲ɷá£×¨¼ÒÎ§ÈÆÁ÷Ðв¡Ñ§£¬¹úÄÚÍâ²îÒ죬¹ú¼Ê×îнøÕ¹£¬±È¿¨Â³°·ÔÚÖÎÁÆÖеĵØÎ»½øÐÐÁËÉîÈë¿Í¹ÛµÄ²ûÊö¡£É½Î÷Z6×ðÁú¿Ê±ÖÆÒ©Æ¸ÇëJudd W.Moul, ËïÁ¢Ó¢½ÌÊÚΪZ6×ðÁú¿Ê±ÌØÆ¸×¨¼Ò¡£


½ÓÏÂÀ´£¬¶Å¿Ë´óѧÍŶÓÒ»ÐÐÀ´µ½Z6×ðÁú¿Ê±´óÏ㬲ιÛÑо¿Ôº£¬²¢¾ÍÃÚÄòÖ×ÁöÑз¢½øÕ¹½øÐÐ×ù̸¡£

´ó»áÉÏ£¬Ì¨ÍåÆÑÓÀТ½ÌÊÚ¶ÔǰÁÐÏÙ°©ÖÎÁÆÖеĹýÓë²»¼°×ö³ö²ûÊö£¬Ö¸³öÄÚ·ÖÃÚÖÎÁƶÔÓÚǰÁÐÏÙ°©»¼ÕßÉú´æÖÊÁ¿µÄÖØÒªÐÔ¡£³ÂÖÒÐŽÌÊÚ±¨¸æÁËǰÁÐÏÙ°©Àä¶³ÖÎÁÆ300ÀýµÄÖг¤ÆÚËæ·Ã½á¹û¡£½¯ÖǺêÖ÷ÈÎÔò¶ÔÉö°©ÖÎÁÆÖеÄÎÊÌâ½øÐÐÁËÈÈÁÒ̽ÌÖ¡£
Öйúҽʦ±¨¶ÔÒÔÆÑÓÀТΪÊ×µÄר¼ÒÍŶӽøÐÐÁ˲ɷá£×¨¼ÒÎ§ÈÆÌ¨ÍåµØÇøÓë´ó½ÖÎÁÆ´ëÊ©µÄ²îÒì¼°±È¿¨Â³°·µÄ°²È«ÐԵȽøÐÐÁ˿͹۲ûÊö¡£É½Î÷Z6×ðÁú¿Ê±ÖÆÒ©Æ¸ÇëÆÑÓÀТ½ÌÊÚΪZ6×ðÁú¿Ê±ÌØÆ¸×¨¼Ò¡£


Ëæºó£¬Ì¨ÍåÍŶÓÒ»ÐвιÛZ6×ðÁú¿Ê±´óÏò¢×ù̸£¬Ë«·½½»Á÷Á˱ȿ¨Â³°·º£Íâ×¢²á£¬¶ÔÆÑÓÀТ½ÌÊÚÖ÷³ÖµÄÖ²ÎïÒ©È«Çò¶àÖÐÐÄÁÙ´²ÊÔÑé×öÁËÉîÈë̽ÌÖ¡£
ͨ¹ýÕâ´ÎѧÊõ½»Á÷»î¶¯£¬ÃÀ¹ú¶Å¿Ë´óѧÍŶӼ°Ì¨Íą̊´óÍŶӶÔÖйúÃñ×åÖÆÒ©ÆóÒµÓÐÁËеÄÈÏʶ£¬ÔÚ±íʾÇÕÅåµÄͬʱ£¬Ï£ÍûZ6×ðÁú¿Ê±ÖÆÒ©ÄܳÉΪÖйúÖÆÒ©ÆóÒµµÄÓÅÐã´ú±í£¬ÔÚ¹ú¼ÊÎę̀ÉÏ·¢³ö¸ü¶àµÄÉùÒô¡£Z6×ðÁú¿Ê±ÈËÒ²½«½èÖú±¾´Îº£ÄÚÍâѧÕß½»Á÷µÄÆõ»ú£¬×ö´ó¡¢×öǿѧÊõ£¬ÎªÖйúµÄ½¡¿µÊÂÒµíÆíÂǰÐУ¡
5ÔÂ5ÈÕ-7ÈÕ£¬±±¾©´óѧµÚÈýÒ½ÔºµÚ¶þ½ìÃÚÄòϵÖ×ÁöרÌâÑÐÌÖ»áÔÚ¾©ÕÙ¿ª¡£ÃÀ¹ú¶Å¿Ë´óѧǰÁÐÏÙÖÐÐÄÖ÷ÈÎ Judd W. Moul¡¢ÃÀ¹úÈý̩ҽѧÊý¾ÝÑо¿ËùÊ×ϯ¿ÆÑ§¼ÒËïÁ¢Ó¢½ÌÊÚ¡¢Ì¨Íą̊´óҽѧԺ¸½ÉèÒ½ÔºÖ÷ÈÎÆÑÓÀТ½ÌÊÚ¡¢Öйú¹¤³ÌԺԺʿ/ɽ¶«Ê¡Ö×ÁöÒ½ÔºÔº³¤ÓÚ½ðÃ÷½ÌÊÚ¡¢ÖлªÒ½Ñ§»áÃÚÄòÍâ¿ÆÑ§·Ö»áºòÈÎÖ÷ÈÎίԱ»Æ½¡½ÌÊÚ¡¢°²»ÕÒ½¿Æ´óѧµÚÒ»¸½ÊôÒ½ÔºÊé¼ÇÁº³¯³¯½ÌÊÚµÈÖî¶àº£ÄÚÍâ¶¥¼âר¼Ò³öϯ£¬È«¹úËİٶàÃûÃÚÄòÍâ¿ÆÒ½Ê¦²Î»á¡£±±¾©´óѧµÚÈýÒ½ÔºÃÚÄòÍâ¿ÆÖ÷ÈÎÂíºÁÖ½ÌÊÚΪ´ó»áÖ÷ϯ¡£

Judd W.MoulÖ¸³ö£ºÏÖ´úǰÁÐÏÙ°©¸ùÖÎÊõÐ뽫ÆäÄÉÈëµ½Ò»¸ö¶àѧ¿Æ¡¢¶àÄ£¿éµÄÕïÁƼƻ®µ±ÖС£ÔÚÄÚ·ÖÃÚÖÎÁƺÍRPÓÐЧÐÔÖÐÌá³öÁËÁ½Ïî×î¼ÑµÄÖ§³ÖÊý¾Ý£ºECOG¡ª3886 ÊÔÑé¡¢±È¿¨Â³°·£¨150mg£©EPCÊÔÑé¡£¶øÐÂÓ¢¸ñÀ¼ÔÓÖ¾2017Äê2Ô¹«²¼µÄ·ÅÁÆÁªºÏ±È¿¨Â³°·150mg Qd µÄÑÖ¤Ñо¿½á¹û±íÃ÷150mg Qd¿ÉÒÔ¸ø»¼Õß´øÀ´¸ü¶àµÄÑ¡Ôñ¡£Óë»áÕß·×·×ÔĶÁ¸ÃÎÄÕ³éÓ¡°æ¡£
ǰÃÀ¹úʳƷҩƷ¹ÜÀí¾Ö£¨FDA£©ÆÀÉó×鳤/ÃÀ¹ú¶Å¿Ë´óѧǰÁÐÏÙÖÐÐÄÊý¾Ý¿âºÍ×éÖ¯¿âÖ÷ÈÎËïÁ¢Ó¢½ÌÊÚ×÷¡°±±ÃÀ°©Ö¢´óÊý¾ÝºÍÓ¦ÓöÔÖйúµÄÆôʾ¡±Ö÷Ìⱨ¸æ¡£
ÌÀƽ¡¢¸µÇ¿µÈ¶Å¿Ë´óѧÍŶÓר¼ÒÕ¹¿ªÁËÈÈÁÒÌÖÂÛ£¬¶ÔÊÀ½ç×îнøÕ¹£¬ÃÀ¹úǰÁÐÏÙ°©´óÊý¾Ý¶ÔÖйúµÄÆôʾ¡¢T1HGºÍT1G3Ö×ÁöµÄ²¡ÀíÑ§ÌØÕ÷×÷Á˾«²Ê»¥¶¯¡£Öйúҽʦ±¨¶ÔÒÔJudd W.MoulΪÊ׵ĶſËÍŶӽøÐÐÁ˲ɷá£×¨¼ÒÎ§ÈÆÁ÷Ðв¡Ñ§£¬¹úÄÚÍâ²îÒ죬¹ú¼Ê×îнøÕ¹£¬±È¿¨Â³°·ÔÚÖÎÁÆÖеĵØÎ»½øÐÐÁËÉîÈë¿Í¹ÛµÄ²ûÊö¡£É½Î÷Z6×ðÁú¿Ê±ÖÆÒ©Æ¸ÇëJudd W.Moul, ËïÁ¢Ó¢½ÌÊÚΪZ6×ðÁú¿Ê±ÌØÆ¸×¨¼Ò¡£


½ÓÏÂÀ´£¬¶Å¿Ë´óѧÍŶÓÒ»ÐÐÀ´µ½Z6×ðÁú¿Ê±´óÏ㬲ιÛÑо¿Ôº£¬²¢¾ÍÃÚÄòÖ×ÁöÑз¢½øÕ¹½øÐÐ×ù̸¡£

´ó»áÉÏ£¬Ì¨ÍåÆÑÓÀТ½ÌÊÚ¶ÔǰÁÐÏÙ°©ÖÎÁÆÖеĹýÓë²»¼°×ö³ö²ûÊö£¬Ö¸³öÄÚ·ÖÃÚÖÎÁƶÔÓÚǰÁÐÏÙ°©»¼ÕßÉú´æÖÊÁ¿µÄÖØÒªÐÔ¡£³ÂÖÒÐŽÌÊÚ±¨¸æÁËǰÁÐÏÙ°©Àä¶³ÖÎÁÆ300ÀýµÄÖг¤ÆÚËæ·Ã½á¹û¡£½¯ÖǺêÖ÷ÈÎÔò¶ÔÉö°©ÖÎÁÆÖеÄÎÊÌâ½øÐÐÁËÈÈÁÒ̽ÌÖ¡£
Öйúҽʦ±¨¶ÔÒÔÆÑÓÀТΪÊ×µÄר¼ÒÍŶӽøÐÐÁ˲ɷá£×¨¼ÒÎ§ÈÆÌ¨ÍåµØÇøÓë´ó½ÖÎÁÆ´ëÊ©µÄ²îÒì¼°±È¿¨Â³°·µÄ°²È«ÐԵȽøÐÐÁ˿͹۲ûÊö¡£É½Î÷Z6×ðÁú¿Ê±ÖÆÒ©Æ¸ÇëÆÑÓÀТ½ÌÊÚΪZ6×ðÁú¿Ê±ÌØÆ¸×¨¼Ò¡£


Ëæºó£¬Ì¨ÍåÍŶÓÒ»ÐвιÛZ6×ðÁú¿Ê±´óÏò¢×ù̸£¬Ë«·½½»Á÷Á˱ȿ¨Â³°·º£Íâ×¢²á£¬¶ÔÆÑÓÀТ½ÌÊÚÖ÷³ÖµÄÖ²ÎïÒ©È«Çò¶àÖÐÐÄÁÙ´²ÊÔÑé×öÁËÉîÈë̽ÌÖ¡£
ͨ¹ýÕâ´ÎѧÊõ½»Á÷»î¶¯£¬ÃÀ¹ú¶Å¿Ë´óѧÍŶӼ°Ì¨Íą̊´óÍŶӶÔÖйúÃñ×åÖÆÒ©ÆóÒµÓÐÁËеÄÈÏʶ£¬ÔÚ±íʾÇÕÅåµÄͬʱ£¬Ï£ÍûZ6×ðÁú¿Ê±ÖÆÒ©ÄܳÉΪÖйúÖÆÒ©ÆóÒµµÄÓÅÐã´ú±í£¬ÔÚ¹ú¼ÊÎę̀ÉÏ·¢³ö¸ü¶àµÄÉùÒô¡£Z6×ðÁú¿Ê±ÈËÒ²½«½èÖú±¾´Îº£ÄÚÍâѧÕß½»Á÷µÄÆõ»ú£¬×ö´ó¡¢×öǿѧÊõ£¬ÎªÖйúµÄ½¡¿µÊÂÒµíÆíÂǰÐУ¡
